Atopic dermatitis (AD) is the most common allergic disease of dogs, affecting approximately 10% of animals resulting in 15-20 million sufferers from the disease in Europe and US alone. Extensive itching causes the dog to scratch which results in loss of fur and secondary infections of the skin, accelerating the symptoms. AD not only affects the well being of dogs but also impacts the quality of life of their owners. A monoclonal antibody against one of the disease-associated molecules has been licensed for use in dogs for the treatment of AD. Hence, we aim at the development of a vaccine to induce antibodies against the disease-associated target molecule using our novel vaccine technology. Development of the CAD vaccine has been further advanced through a commercialization, manufacture, and distribution agreement with Benchmark Holdings PLC who has an exclusive worldwide license from HypoPet to develop and commercialize the CAD vaccine (termed VC002). We have made significant progress on the development of the CAD vaccine. Lead optimization and a pilot study in dogs has been already successfully completed. Proof of concept in a canine model of atopic dermatitis has been achieved and the data published (Bachmann, M.F., A. Zeltins, G. Kalnins, I. Balke, N. Fischer, A. Rostaher, K. Tars, and C. Favrot. 2018. Vaccination against IL-31 for the treatment of atopic dermatitis in dogs. J Allergy Clin Immunol)
Atopic dermatitis (AD) in dogs
Feline atopic dermatitis (FAD) in cats
Feline atopic dermatitis (FAD) is an allergic disease driven by environmental allergens which results in chronic pruritic skin disorders in cats. Treatment is life-long and has included allergen avoidance, symptomatic treatment, desenitization therapy and immunosuppressive therapies. Current treatments had limited efficacy and were associated with side-effect. The prevalence of FAD is thought to be around 1-2% with a median age of onset of ~ 3 years. HypoPet is developing several vaccines targeting different molecules involved in feline atopic dermatitis conditions.